GDC-0134

SI-7319

GDC-0134, >98% (HPLC)

CAS No. : [1637394-01-4]

Synonyms : RG-6000

IUPAC Name : 5-(6-((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-2-(3,3-difluoropyrrolidin-1-yl)pyrimidin-4-yl)-3-(difluoromethoxy)pyridin-2-amine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : GDC‑0134 crosses the blood–brain barrier and selectively modulates DLK, blocking DLK/JNK pathway activation and attenuating retrograde axonal degeneration signaling. It exhibits neuroprotective activity, including reduced TDP‑43 aggregation and improved neuromuscular junction integrity in motor neurons. These properties support its application in ALS, Alzheimer’s disease, and other neurodegenerative disease models.

References : Hoffmann-Emery F. et al.: Organic Process Research & Development, 26(2), 313-322, 2022; Minaei A. et al.: Neural Regeneration Research, 21(8), 3515-3516, 2026; Palomo V. et al.: British Journal of Pharmacology, 178(6), 1316-1335, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.