GDC-0575 dihydrochloride

SI-6827

GDC-0575 dihydrochloride, >98% (HPLC)

CAS No. : [1657014-42-0]

Synonyms : ARRY-575 dihydrochloride; RG-7741 dihydrochloride

IUPAC Name : (R)-N-(4-(3-Aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropane-2,2,3,3-d4-1-carboxamide dihydrochloride

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : GDC‑0575 dihydrochloride selectively targets Chk1 with nanomolar potency (IC₅₀ = 1.2 nM) and is orally bioavailable. It displays significant antitumor activity, making it a valuable tool for investigating Chk1‑mediated DNA‑damage signaling and therapeutic sensitization strategies.

References : Oo Z. Y. et al.: Clin. Cancer Res., 24(12), 2901-2912, 2018; Di Tullio A. et al.: Nat. Commun., 8(1), 1679, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.