GDC-2394

SI-7188

GDC-2394, >98% (HPLC)

CAS No. : [2238822-07-4]

IUPAC Name : (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : GDC‑2394 is an orally active and selective NLRP3 inhibitor that also suppresses IL‑1β production with IC₅₀ values of 0.4 µM (human) and 0.1 µM (mouse). It inhibits NLRP3‑induced caspase‑1 activation without affecting NLRC4 inflammasome signaling and is suitable for studies of gouty arthritis.

References : McBride C. et al.: J. Med. Chem., 65(21), 14721-14739, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.