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Gemfibrozil 1-O-beta-glucuronide

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SI-6621

Gemfibrozil 1-O-β-glucuronide, >98% (HPLC)

CAS No. : [91683-38-4]

IUPAC Name : (2R,3R,4R,5S,6R)-6-((5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

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Chemical Properites
Mol. Formula :
C21H30O9
Mol. Weight :
426.46
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Gemfibrozil 1‑O‑β‑Glucuronide is a major Gemfibrozil metabolite that strongly inhibits CYP2C8 with an IC₅₀ of 4.07 µM. Its pronounced inhibitory activity makes it an important tool for evaluating Gemfibrozil‑associated metabolic interactions and P450‑dependent clearance pathways.

References : Shitara Y. et al.: J. Pharmacol. Exp. Ther., 311(1), 228-36, 2004; Baer B. R. et al.: Chem. Res. Toxicol., 22(7), 1298-309, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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