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Gemfibrozil

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SI-6617

Gemfibrozil, >98% (HPLC)

CAS No. : [25812-30-0]

Synonyms : CI-719

IUPAC Name : 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid

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Chemical Properites
Mol. Formula :
C15H22O3
Mol. Weight :
250.34
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Gemfibrozil activates PPAR‑α and is widely used as a lipid‑modifying agent. It also inhibits multiple CYP450 isoforms with micromolar Ki values—CYP2C9 (5.8 µM), CYP2C19 (24 µM), CYP2C8 (69 µM), and CYP1A2 (82 µM)—highlighting its potential to influence xenobiotic metabolism.

References : Pahan K. et al.: J. Biol. Chem., 277(48), 45984-91, 2002, Epub 2002; Almad A. et al.: Exp. Neurol., 232(2), 309-17, 2011; Wang J. S. et al.: Drug Metab. Dispos., 30(12), 1352-6, 2002.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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