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Givinostat hydrochloride

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SL-1613

Givinostat hydrochloride, >98%

CAS No. : [199657-29-9]

MDL No. : MFCD28502062

Synonyms : ITF-2357 hydrochloride

IUPAC Name : (6-((Diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate hydrochloride

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Chemical Properites
Mol. Formula :
C24H27N3O4 . HCl
Mol. Weight :
457.95
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Givinostat hydrochloride is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.

References : Li S. et al.: J. Biol. Chem., 290(4), 2368-2378, 2015; Wang Y.G. et al.: World J. Gastroenterol., 21(27), 8326-8339, 2015; Leoni F. et al.: Mol. Med., (1-12), 1-15, 2005.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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