GLP‑1R agonist

SI-8064

GLP‑1R agonist, >98% (HPLC)

IUPAC Name : (R)-4-Fluoro-2-((4-(6-((2-methoxy-4-(trifluoromethyl)benzyl)oxy)pyridin-2-yl)-5,6-dihydro-1,2,4-triazin-1(4H)-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a high‑potency, selective GLP‑1R agonist from a new 5,6‑dihydro‑1,2,4‑triazine series designed to overcome danuglipron’s hERG liability and short action. It shows 7‑fold stronger cAMP activation than danuglipron, has acceptable drug‑like properties, and produces long‑lasting glucose‑lowering and appetite‑suppressing effects in hGLP‑1R knock‑in mice, supporting its potential for T2DM and obesity therapy.

References : Chen L. et al.: : J. Med. Chem., 66(12), 7988-8010, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.