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Glyco obeticholic acid

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Glyco obeticholic acid, >98%

Synonyms : Glycine 6-ethylchenodeoxy cholate impurity

IUPAC Name : ((4S)-4-((3R,6R,7R,10S,13R)-6-Ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoyl)glycine

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Chemical Properites
Mol. Formula :
C28H47NO5
Mol. Weight :
477.69
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Glyco-obeticholic acid is an active glycine-conjugated metabolite of Obeticholic acid, which is acting as a potent farnesoid X receptor (FXR) agonist. Obeticholic acid is used to treat primary biliary cholangitis and under study for liver fibrosis.

References : Fiorucci S. et al.: J. Pharmacol Exp Ther., 313(2), 604-612, 2005; Ghebremariam Y. T. et al.: PLoS One 8(4), e60653, 2013; Verbeke L. et al.: Am J. Pathol.,185(2), 409-419, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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