GNE-049

SI-6896

GNE-049, >98% (HPLC)

CAS No. : [1936421-41-8]

IUPAC Name : 1-(3-(7-(Difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : GNE‑049 potently targets the CBP bromodomain (IC₅₀ = 1.1 nM, TR‑FRET) and demonstrates robust cellular engagement in BRET assays (IC₅₀ = 12 nM). Its weak activity against BRD4(1) (IC₅₀ = 4200 nM) highlights its high selectivity for CBP over BET family bromodomains.

References : Romero F. A. et al.: J. Med. Chem., 60(22), 9162-9183, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.