GNE-064

SI-7158

GNE-064, >98% (HPLC)

CAS No. : [1997321-20-6]

IUPAC Name : (R)-1-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-methylpiperazin-1-yl)ethan-1-one

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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : GNE‑064 selectively targets SMARCA4, SMARCA2, and PBRM1 bromodomains, showing potent inhibition of SMARCA4 (IC₅₀ = 0.035 µM) and SMARCA2 (EC₅₀ = 0.10 µM). It binds these bromodomains with low‑micromolar to sub‑micromolar affinity and is well suited for mechanistic studies and chemical‑probe applications.

References : Taylor A. M. et al.: J. Med. Chem., 65(16), 11177-11186, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.