GNE-0749

SI-6510

GNE-0749, >98% (HPLC)

CAS No. : [2719667-13-5]

IUPAC Name : 1-(3,3-Dimethylbutyl)-3-(2-fluoro-5-((5-fluoro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)-4-methylphenyl)urea

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : GNE‑0749 is a potent, orally bioavailable pan‑RAF inhibitor with a Ki of 0.061 nM against CRAF. It stabilizes a DFG‑out/αC‑helix‑in conformation to inhibit RAF dimer signaling and prevent paradoxical MAPK pathway activation. GNE‑0749 suppresses downstream MEK/ERK/RSK signaling and is suitable for studies involving KRASG12C‑driven cancers

References : Huestis M. P. et al.: J. Med. Chem., 64(7), 3940-3955, 2021; Harwood J. S. et al.: Int. J. Mol Sci., 24(8), 7373, 2023; Huestis M. P. et al.: ACS Med. Chem. Lett., 12(5), 791-797, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.