GNE-0877

SI-6376

GNE-0877, >98% (HPLC)

CAS No. : [1374828-69-9]

IUPAC Name : 2-Methyl-2-(3-methyl-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)propanenitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : GNE-0877 selectively inhibits LRRK2 with sub‑nanomolar affinity (K_i = 0.7 nM) and strong oral and brain exposure. These properties make it a valuable tool compound for probing LRRK2‑dependent pathways in neurobiology and neurodegenerative disease models.

References : Estrada A. A. et al.: J. Med. Chem., 57(3), 921-36, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.