GNE-149

SI-6751

GNE-149, >98% (HPLC)

CAS No. : [1953132-75-6]

IUPAC Name : (1R,3R)-1-(2,6-Difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)oxy)phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : GNE‑149 potently antagonizes ERα (IC₅₀ = 0.053 nM) and induces receptor degradation, consistent with its classification as a SERD. Its strong oral bioavailability and ERα‑targeting profile support its use in breast cancer research.

References : Jun. Liang. et al.: ACS Med. Chem. Lett., 11(6), 1342-1347, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.