GNE-207

SI-8084

GNE-207, >98% (HPLC)

CAS No. : [2158266-58-9]

IUPAC Name : 5-(8-(5-Acetyl-1-(tetrahydro-2H-pyran-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)isoquinolin-3-yl)-N-methylpicolinamide

Price And Availability
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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : GNE‑207 is an orally bioavailable CBP bromodomain inhibitor with nanomolar potency (IC₅₀= 1 nM) and exceptional selectivity over BRD4(1). It effectively suppresses MYC expression in MV‑4‑11 cells (EC₅₀= 18 nM), making it a valuable tool for probing CBP‑mediated transcription and oncogenic signaling.

References : Lai K. W. et al.: Bioorg. Med. Chem. Lett., 28(1), 15-23, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.