GNE-3511

SI-7317

GNE-3511, >98% (HPLC)

CAS No. : [1496581-76-0]

IUPAC Name : 2-((6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : GNE‑3511 potently inhibits DLK with sub‑nanomolar affinity (K_i= 0.5 nM) and demonstrates excellent oral bioavailability and brain penetration. Its pharmacological profile makes it valuable for studying neuronal stress signaling and neurodegeneration.

References : Patel S. et. al.: J. Med. Chem., 58(1), 401-18, 2015; Chen Jiang et al.: J. Innate Immun., 13(5), 259-268, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.