GNE-886

SI-6133

GNE-886, >98% (HPLC)

CAS No. : [2101957-05-3]

IUPAC Name : 6-Allyl-N-(1-(6-(3-methoxyphenyl)pyrimidin-4-yl)piperidin-4-yl)-N-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-carboxamide

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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : GNE‑886 selectively targets the CECR2 bromodomain with nanomolar potency (IC₅₀ = 16 nM; EC₅₀ = 370 nM) and displays weaker inhibition of BRD9 (IC₅₀ = 1.6 µM). It serves as a useful tool compound for probing CECR2‑mediated transcriptional and chromatin‑regulatory pathways.

References : Crawford T. D. et al.: ACS Med. Chem. Lett., 8(7), 737-741, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.