GNF-2133 hydrochloride

SI-6395

GNF-2133 hydrochloride, >98% (HPLC)

CAS No. : [2561414-57-9]

IUPAC Name : 4-Ethyl-N-(4-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)pyridin-2-yl)piperazine-1-carboxamide hydrochloride

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : GNF-2133 hydrochloride selectively inhibits DYRK1A with low‑nanomolar potency while sparing GSK3β. It enhances β‑cell proliferation and insulin secretory capacity, leading to improved glucose handling in preclinical models. Its pharmacological profile supports its use in exploring β‑cell biology and therapeutic strategies for type 1 diabetes.

References : Liu Y. A. et al.: J. Med. Chem., 63(6), 2958-2973, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.