GPR55 agonist

SI-7374

GPR55 agonist, >98% (HPLC)

IUPAC Name : (R)-5-(3-((1-(4-Fluorophenyl)ethyl)amino)-1,2,4-triazin-6-yl)-3-methylbenzo[d]oxazol-2(3H)-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a brain‑penetrant, nanomolar‑potency GPR55 agonist identified through high‑throughput screening and optimized for selectivity over CB1/CB2. It exhibits biased signaling, with defined β‑arrestin recruitment and desensitization properties, enabling mechanistic probing of GPR55 function. It achieves unbound brain concentrations above its GPR55 EC₅₀ after oral dosing, making it a useful tool compound for studying GPR55 biology in the CNS, including its potential role in Parkinson’s disease motor circuitry.

References : Hewer C. R. et al.: J. Med. Chem., 66(18), 12858-12876, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.