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GRL-0667 (S)-enantiomer

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SL-7492

GRL-0667 (S)-enantiomer, >98%

CAS No. : [1233939-90-6]

IUPAC Name : (S)-N-(Benzo[d][1,3]dioxol-5-ylmethyl)-1-(1-(naphthalen-1-yl)ethyl)piperidine-4-carboxamide

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Chemical Properites
Mol. Formula :
C26H28N2O3
Mol. Weight :
416.52
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an (S)-enantiomer of GRL-0667. Interestingly, displays nearly equivalent enzymatic and antiviral potencies to its (R)-enantiomer. GRL-0667 is a potent, noncovalent, competitive inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro). It is a useful COVID-19 research chemical.

References : Ghosh A. K. et al.: J. Med. Chem., 53(13), 4968-4979, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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