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GS-9822

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SI-7021

GS-9822, >98% (HPLC)

CAS No. : [2219362-41-9]

IUPAC Name : (R)-2-(tert-Butoxy)-2-(7-(4-chlorophenyl)-5-methyl-2-(1-methyl-3-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indazol-5-yl)benzo[d]thiazol-6-yl)acetic acid

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Chemical Properites
Mol. Formula :
C36H39ClN4O4S
Mol. Weight :
659.24
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : GS‑9822 functions as a potent antiviral agent with nanomolar activity against wild‑type HIV‑1. It effectively blocks the LEDGF/p75–integrase interaction (IC50= 0.07 µM) and demonstrates high metabolic stability in vitro. In vivo, GS‑9822 exhibits advantageous oral pharmacokinetics with low systemic clearance in rats, dogs, and monkeys.

References :
Bruggemans A. et al.: Antimicrob. Agents Chemother., 65(5), e02328-20, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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