GSK-046

SI-6221

GSK-046, >98% (HPLC)

CAS No. : [2474876-09-8]

Synonyms : iBET-BD2

IUPAC Name : 4-Acetamido-3-fluoro-N-((1r,4S)-4-hydroxycyclohexyl)-5-((S)-1-phenylethoxy)benzamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : GSK-046 selectively targets the BD2 domains of BET proteins with nanomolar potency (BRD4‑BD2 IC₅₀ = 49 nM) and is orally active. It functions as an immunomodulatory probe for studying BD2‑driven transcriptional regulation and inflammatory signaling.

References : Omer G. et. al.: Science, 368(6489), 387-394, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.