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GSK-1059865

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SI-5711

GSK-1059865, >98% (HPLC)

CAS No. : [1191044-58-2]

IUPAC Name : ((2S,5S)-2-(((5-Bromopyridin-2-yl)amino)methyl)-5-methylpiperidin-1-yl)(3-fluoro-2-methoxyphenyl)methanone

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Chemical Properites
Mol. Formula :
C20H23BrFN3O2
Mol. Weight :
436.33
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : GSK-1059865 is a potent orexin 1 (OX1) receptor antagonist. This can be used to develop a potential candidate for the treatment of compulsive disorders such as alcoholism and other addictions.

References : Lopez M. F. et al.: Brain Res., 1636, 74-80, 2016; Piccoli L. et al.: Neuropsychopharmacology 37(9), 1999-2011, 2012; Gozzi A. et al.: Neuropsychopharmacology 38(11), 2120-30, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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