GSK-180736A

SI-6378

GSK-180736A, >98% (HPLC)

CAS No. : [817194-38-0]

IUPAC Name : 4-(4-Fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : GSK-180736A inhibits ROCK1 with low‑nanomolar potency and selectively blocks GRK2 in an ATP‑competitive manner (IC₅₀ = 0.77 µM). This dual profile makes it a useful tool compound for dissecting ROCK‑dependent cytoskeletal pathways and GRK2‑regulated GPCR signaling.

References : Waldschmidt H. V. et al.: J. Med. Chem., 59(8), 3793-807, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.