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GSK 224876

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SI-5916

GSK 224876, >98% (HPLC)

CAS No. : [1097733-15-7]

Synonyms : IDX-989

IUPAC Name : Methyl (E)-(2-carbamoyl-5-chloro-1H-indol-3-yl)(3-(2-cyanovinyl)-5-methylphenyl)phosphinate

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Chemical Properites
Mol. Formula :
C20H17ClN3O3P
Mol. Weight :
413.8
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : GSK-224876 is a novel next-generation nonnucleoside reverse transcriptase (NNRT) inhibitor with activity against efavirenz-resistant strains.

References : Margolis D. A. et al.: Antivir Ther.,19(1), 69-78, 2014; Usach I. et al.: J. Int. AIDS Soc.,16, 1-14, 2013; Castellino S. et al.: Chem Res Toxicol., 26(2), 241-51; 2013; Zala C. et al.: Antimicrob Agents Chemother., 56(5), 2570-5, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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