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GSK-2256294A

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SI-5490

GSK-2256294A, >98% (HPLC)

CAS No. : [1142090-23-0]

MDL No. : MFCD27987923

Synonyms : GSK 2256294

IUPAC Name : (1R,3S)-N-(4-Cyano-2-(trifluoromethyl)benzyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexane-1-carboxamide

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Chemical Properites
Mol. Formula :
C21H24F3N7O
Mol. Weight :
447.47
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : GSK-2256294A is a potent, reversible, tight binding inhibitor of isolated recombinant human sEH (soluble epoxide hydrolase) (IC50 = 27 pM; t1/2 = 121 min) and displays potent inhibition against the rat (IC50 = 61 pM) and murine (IC50 = 189 pM) orthologs of sEH.

References : Podolin P. L. et al.: Prostaglandins Other Lipid Mediat., 104-105, 25-31, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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