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GSK-256066

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SI-5175

GSK-256066, >98% (HPLC)

CAS No. : [801312-28-7]

MDL No. : MFCD18206923

IUPAC Name : 6-((3-(Dimethylcarbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide

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Chemical Properites
Mol. Formula :
C27H26N4O5S
Mol. Weight :
518.59
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : GSK-256066 is a selective and high-affinity phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 3.2 pM for PDE4B. GSK-256066 is developed for the research of chronic obstructive pulmonary disease (COPD).

References : Tralau-Stewart C. J. et al.: J. Pharmacol Exp Ther., 337(1), 145-154, 2011;
Nials A. T. et al.: J. Pharmacol Exp Ther., 337(1), 137-144, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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