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GSK-2606414

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SI-5724

GSK-2606414, >98% (HPLC)

CAS No. : [1337531-36-8]

MDL No. : MFCD25976926

Synonyms : GSK'414

IUPAC Name : 1-(5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethyl)phenyl)ethan-1-one

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Chemical Properites
Mol. Formula :
C24H20F3N5O
Mol. Weight :
451.45
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : GSK-2606414 is a cell-permeable and orally available protein kinase R-like endoplasmic reticulum (ER) kinase (PERK) inhibitor with an IC50 of 0.4 nM.

References : Axten J. M. et al.: J Med Chem., 55(16), 7193-207, 2012; Zhang M. et al.: Cell Host Microbe 22(6), 766-776.e4, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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