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GSK-2983559-AM

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SI-5073

GSK-2983559-AM, >98% (HPLC)

CAS No. : [1423186-80-4]

MDL No. : MFCD30489727

IUPAC Name : 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethan-1-ol

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Chemical Properites
Mol. Formula :
C21H22N4O4S2
Mol. Weight :
458.55
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a active metabolite of GSK-2983559. A potent, specific and oral active receptor interacting protein 2 (RIP2) kinase inhibitor. GSK-2983559 has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.

References : Haile P. A. et al.: J. Med Chem., 62(14), 6482-6494, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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