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GSK-3368715 dihydrochloride

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SI-6672

GSK-3368715 dihydrochloride, >98% (HPLC)

CAS No. : [1628925-77-8]

Synonyms : EPZ-019997 dihydrochloride

IUPAC Name : N1-((3-(4,4-Bis(ethoxymethyl)cyclohexyl)-1H-pyrazol-4-yl)methyl)-N1,N2-dimethylethane-1,2-diamine dihydrochloride

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Chemical Properites
Mol. Formula :
C20H38N4O2 • 2HCl
Mol. Weight :
439.47
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : GSK-3368715 dihydrochloride inhibits type I PRMTs through a reversible, SAM‑uncompetitive mechanism, with low‑nanomolar potency for PRMT1, PRMT3, PRMT6, and PRMT8. It reprograms arginine methylation patterns, alters splicing, and shows strong antiproliferative activity in cancer research.

References : Fedoriw A. et al.: Cancer Cell, 36(1), 100-114.e25, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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