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GSK-3527497

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SI-5502

GSK-3527497, >98% (HPLC)

CAS No. : [2215855-22-2]

IUPAC Name : 4-(((3S,4S)-4-(Aminomethyl)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)-2-fluorobenzonitrile

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Chemical Properites
Mol. Formula :
C17H16ClFN4O4S
Mol. Weight :
426.85
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : GSK-3527497 is a novel potent and selective inhibitor of transient receptor potential vanilloid-4 (TRPV4) for the potential treatment of heart failure and respiratory diseases.

References : Brooks A. C. et al.: J. Med. Chem., 62(20), 9270-9280, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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