GSK-356278

SI-7477

GSK-356278, >98% (HPLC)

CAS No. : [720704-34-7]

IUPAC Name : 5-(5-((2,4-Dimethylthiazol-5-yl)methyl)-1,3,4-oxadiazol-2-yl)-1-ethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : GSK-356278 potently inhibits PDE4 isoforms (pIC₅₀ = 8.6–8.8) and is both orally bioavailable and brain‑penetrant. It reduces inflammatory signaling and produces anxiolytic and pro‑cognitive effects, making it a valuable tool compound for studying PDE4‑mediated pathways in inflammation and CNS disorders.

References : Rutter A. R. et al.: J. Pharmacol. Exp. Ther., 350(1), 153-63, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.