GSK-3beta inhibitor 13

SI-7294

GSK-3β inhibitor 13, >98% (HPLC)

CAS No. : [2227316-74-5]

IUPAC Name : N-(4-(2-Methylmorpholino)pyridin-3-yl)-2-phenylimidazo[1,2-b]pyridazine-8-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a potent GSK‑3β inhibitor from an imidazo[1,2‑b]pyridazine series developed through structure‑guided optimization. It demonstrates strong GSK‑3β inhibitory activity and is brain‑penetrant and orally bioavailable. In a triple‑transgenic Alzheimer’s disease mouse model, It significantly reduced phosphorylated tau levels, confirming effective target engagement in vivo. These properties position it is as a promising CNS‑active GSK‑3β inhibitor for further preclinical evaluation in tau‑driven neurodegenerative disease.

References : Hartz A. R. et al.: J. Med. Chem., 66(6), 4231−4252, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.