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GSK-547

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SI-5723

GSK-547, >98% (HPLC)

CAS No. : [2226735-55-1]

Synonyms : GSK'547

IUPAC Name : (S)-6-(4-(5-(3,5-Difluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbonyl)piperidin-1-yl)pyrimidine-4-carbonitrile

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Chemical Properites
Mol. Formula :
C20H18F2N6O
Mol. Weight :
396.40
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : GSK-547 is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIPK1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.

References : Wang W. et al.: Cancer Cell 34(5), 757-774.e7, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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