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GSK-583

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SI-6344

GSK-583, >98% (HPLC)

CAS No. : [1346547-00-9]

IUPAC Name : 6-(Tert-butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine

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Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C20H19FN4O2S
Mol. Weight :
398.46
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : GSK-583 potently and selectively inhibits RIP2 kinase at low‑nanomolar concentrations and reduces TNF‑α and IL‑6 release with an IC50 of 200 nM. It is widely used to probe RIP2‑mediated inflammatory responses.

References : Haile P. A et al.: J. Med. Chem., 59(10), 4867-80, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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