GSK-8470

SI-6863

GSK-8470, >98% (HPLC)

CAS No. : [1276664-65-3]

IUPAC Name : (3aS,6aR)-5-((E)-Oct-4-en-4-yl)-N,4-diphenyl-2,3,6,6a-tetrahydropentalen-3a(1H)-amine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : GSK-8470 is a structurally optimized RORγt inverse agonist designed to inhibit Th17 lineage commitment and downstream IL‑17 cytokine expression. GSK‑8470 serves as a research tool for dissecting RORγt‑regulated immune pathways and supporting medicinal‑chemistry programs targeting Th17‑driven inflammation.

References : Mays S. G. et al.: J. Biol Chem., 291(49), 25281-25291, 2016; Whitby R. J. et al.: J. Med Chem., 49(23), 6652-5, 2006.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.