GSK-872

SI-5209

GSK-872, >98% (HPLC)

CAS No. : [1346546-69-7]

MDL No. : MFCD30481302

IUPAC Name : N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine

Price And Availability
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10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.

References : Mandal P. et al.: Mol Cell., 56(4), 481-495, 2014; Arora D. et al.: Biochem Biophys Res Commun., 479(2), 217-223, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.