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GSK-923295

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SI-5402

GSK-923295, >98% (HPLC)

CAS No. : [1088965-37-0]

MDL No. : MFCD16038931

IUPAC Name : 3-Chloro-N-((S)-1-(2-(dimethylamino)acetamido)-3-(4-(8-((S)-1-hydroxyethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-4-isopropoxybenzamide

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Chemical Properites
Mol. Formula :
C32H38ClN5O4
Mol. Weight :
592.14
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : GSK-923295 is a special, allosteric inhibitor of centromere-associated protein-E (CENP-E) kinesin motor ATPase activity, with Ki of 3.2±0.2 nM and 1.6± 0.1 nM for human and canine, respectively. GSK923295 as an antiproliferative agent.

References : Wood K. W. et al. Proc Natl Acad Sci U S A. 107(13), 5839-44, 2010; Mayes P. A. et al.: Int. J. Cancer.,132(3), E149-57, 2013; Balamuth N. J. et al.: Cancer Res., 70(7), 2749-58, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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