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GTA Degradation impurity 1

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GTA Degradation impurity 1, >98%

CAS No. : [174227-15-7]

IUPAC Name : 6-Amino-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-ol

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Chemical Properites
Mol. Formula :
C15H13N5O3
Mol. Weight :
311.3
Appearance :
Pale yellow solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Bosentan, which is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors.

References : Dhillon S. et al.: Am J. Cardiovasc Drugs 9(5), 331-350, 2009; Akamata K. et al. Arthritis Res. Ther., 16(2), R86, 2014; Iglarz M. et al. Life Sci., 118(2), 333-339, 2014; Son G. Y. et al. PLoS One 11(12), e0167713, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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