GTS-21 dihydrochloride

SI-5660

GTS-21 dihydrochloride, >98% (HPLC)

CAS No. : [156223-05-1]

MDL No. : MFCD00941364

IUPAC Name : (E)-3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine dihydrochloride

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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1G	Request A Quote		Back Order	Estimated to ship on 04 October 2026
2G	Request A Quote		In Stock	Estimated to ship on 20 September 2026

Applications : GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti‑inflammatory and cognition‑enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.

References : Briggs C. A. et al.: Pharmacol Biochem Behav., 57(1-2), 231-241, 1997; Zhang R. et al.: J. Pharmacol Exp Ther., 317(3), 1276-1284, 2006; Mei Z. et al.: Oncol Rep., 40(4), 2287-2297, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.