Gusacitinib-d4

SI-6325

Gusacitinib-d₄, >98% (HPLC)

Synonyms : ASN-002-d₄

IUPAC Name : 2-(1-(4-((4-(4-Hydroxypiperidin-1-yl)phenyl-2,3,5,6-d₄)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Gusacitinib‑d₄ is a deuterium‑labelled version of the potent dual SYK/JAK inhibitor Gusacitinib, which shows low‑nanomolar activity against SYK and JAK family kinases. Gusacitinib effectively suppresses inflammatory signaling relevant to atopic dermatitis and is used in research on chronic hand eczema and basal cell carcinoma, while the d₄ analog supports metabolic and mechanistic studies.

References : Xie Z. et al.: J. Med. Chem., 64(3), 1283-1345, 2021; Garcia-Melendo C. et al.: Actas. Dermo-Sifiliográficas., 112(6), 503-515, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.