H3B-6545

SI-6749

H3B-6545, >98% (HPLC)

CAS No. : [2052130-80-8]

IUPAC Name : (E)-N,N-Dimethyl-4-((2-((5-((Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenylbut-1-en-1-yl)pyridin-2-yl)oxy)ethyl)amino)but-2-enamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : H3B‑6545 is a potent, orally bioavailable covalent antagonist of ERα that selectively blocks ER‑dependent signaling pathways. Its pharmacological profile supports its use in mechanistic and therapeutic studies of metastatic ER⁺/HER2⁻ breast cancer.

References : Peter G. Smith. et al.: Cancer Res., 77(13), DDT01-04, 2017; Amy H. Kim et al.: J. Pharmacol. Toxicol. Methods, 99, 106595, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.