HDAC inhibitor

SI-7327

HDAC inhibitor, >98% (HPLC)

IUPAC Name : N-Hydroxy-4-((2S)-2-(7-methoxy-3,4,4a,9a-tetrahydrobenzofuro[2,3-c]pyridin-2(1H)-yl)-3-phenylpropanamido)benzamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a 1,2,3,4‑tetrahydrobenzofuro[2,3‑c]pyridine‑based HDAC inhibitor developed through scaffold hopping and multicomponent synthesis. It shows potent HDAC inhibition, strong activity in HCC cell lines (IC₅₀ = 30 nM, Bel‑7402), and robust in vivo efficacy (76% tumor inhibition in Bel‑7402 xenografts, oral, 20 mg/kg, QOD). Mechanistically, it increases histone H3 and α‑tubulin acetylation, inducing apoptosis and autophagy. Docking studies reveal a unique T‑shaped binding mode within HDAC1, supporting as a promising HCC therapeutic candidate.

References : Lai Z. et al.: J. Med. Chem., 66(15), 10791-10807, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.