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Hexametazidine

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SL-4566

Hexametazidine, >98%

CAS No. : [1257-19-8]

Synonyms : 1,4-Bis[(2,3,4-trimethoxyphenyl)methyl]piperazine; Trimetazidine EP impurity B

IUPAC Name : 1,4-Bis(2,3,4-trimethoxybenzyl)piperazine

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Chemical Properites
Mol. Formula :
C24H34N2O6
Mol. Weight :
446.54
Appearance :
Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Trimetazidine (Trimetazidine EP impurity B), which is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase activity and results in a reduction in fatty acid oxidation and a stimulation of glucose oxidation.

References : Kantor P. F. et al.: Circ Res. 86(5), 580-588, 2000; Liu Z. et al.: Metabolism. 65(3), 122-130, 2016; Yang Q. et al.: Int. J. Clin Exp Pathol. 8(4), 3735-3741, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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