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HG-9-91-01

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SI-7502

HG-9-91-01, >98% (HPLC)

CAS No. : [1456858-58-4]

Synonyms : SIK inhibitor 1

IUPAC Name : 1-(2,4-Dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea

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Chemical Properites
Mol. Formula :
C32H37N7O3
Mol. Weight :
567.69
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : HG‑9‑91‑01 potently inhibits SIK1/2/3 with sub‑10‑nM IC50 values and is commonly used to study SIK‑dependent signaling in metabolic regulation, inflammation, and transcriptional control.

References : Clark K. et al.: Proc. Natl. Acad. Sci. U S A., 109(42), 16986-91, 2012; Sundberg T. B. et al.: Proc. Natl. Acad. Sci. U S A., 111(34), 12468-73, 2014; Patel K. et al.: Nat. Commun., 5, 4535, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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