HPG-1860

SI-8157

HPG-1860, >98% (HPLC)

CAS No. : [2226133-29-3]

IUPAC Name : (R)-2-(4-((5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methyl)-2-methylpiperazin-1-yl)-4-methoxybenzo[d]thiazole-6-carboxylic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : HPG-1860 activates FXR with high potency (EC₅₀ = 18 nM) and displays negligible activity toward TGR5 and other nuclear receptors (EC₅₀ > 30 µM). Its strong selectivity and oral activity make it a valuable tool compound for investigating FXR‑mediated pathways in NASH.

References : Mo C. et al.: J. Med. Chem., 66(14), 9363–9375, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.