HPK1 inhibitor

SI-7295

HPK1 inhibitor, >98% (HPLC)

IUPAC Name : 3-(4-((3S,4R)-3-Amino-4-fluoropiperidin-1-yl)-6-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Amino‑6‑aryl pyrrolopyrimidines are novel HPK1 inhibitors discovered through virtual screening and refined by structure‑based design. They target HPK1, a negative regulator of immune signaling, offering a promising strategy for cancer immunotherapy. Optimization of lipophilic efficiency and binding interactions produced potent, drug‑like HPK1 inhibitors suitable for further development as immune‑activating anticancer agents.

References : Gallego A. R. et al.: J. Med. Chem., 66(7), 4888-4909, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.