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Hydroxychloroquine EP impurity F HCl

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Hydroxychloroquine EP impurity F HCl, >98%

Related CAS No. : [6281-58-9] of the free base compound

IUPAC Name : 7-Chloro-4-(2-methylpyrrolidin-1-yl)quinoline hydrochloride

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Chemical Properites
Mol. Formula :
C14H15ClN2 • HCl
Mol. Weight :
283.20
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Chloroquine, which is an antimalarial and anti-inflammatory drug used for malaria and rheumatoid arthritis. Chloroquine inhibits autophagy and toll-like receptors (TLRs), and has demonstrated efficacy against SARS-CoV-2 (COVID-19) infection.

References : Said A. et al.: J. Immunol., 193(12), 6135-43, 2014; Tuomela J. et al.: Oncol Lett., 6(6), 1665-1672, 2013; Mohamed F. E. et al.: Liver Int., 35(3):1063-76, 2015; Colson P. et al.: Int J. Antimicrob Agents 55(4), 105932, 2020; Savarino A. et al.: J. Clin Virol., 20(3), 131-135, 2001.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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