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Hydroxydehydro-nifedipine-lactone

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SL-4277

Hydroxydehydro-nifedipine-lactone, >98%

CAS No. : [34785-00-7]

Synonyms : BAY-h 2228

IUPAC Name : Methyl 2-methyl-4-(2-nitrophenyl)-5-oxo-5,7-dihydrofuro[3,4-b]pyridine-3-carboxylate

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Chemical Properites
Mol. Formula :
C16H12N2O6
Mol. Weight :
328.28
Appearance :
Light yellow solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a metabolite of Nifedipine, which is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.

References : Ding Y. et al.: J. Pharmacol Exp Ther., 292(2), 606-609, 2000; Zhang X. et al.: J. Pharmacol Exp Ther, 281(3), 1247-1256, 1997; Hirata A. et al.: Br. J. Pharmacol., 131(8), 1521-1530,2000; Curtis T. M. et al.: J. Physiol, 532(Pt 3), 609-623, 2001; Suzuki Y. et al.: Jpn J. Pharmacol, 78(4), 435-441, 1998.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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