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SI-6985

Ibiglustat, >98% (HPLC)

CAS No. : [1401090-53-6]

Synonyms : Venglustat; SAR-402671; GZ-402671

IUPAC Name : (S)-Quinuclidin-3-yl (2-(2-(4-fluorophenyl)thiazol-4-yl)propan-2-yl)carbamate

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Chemical Properites
Mol. Formula :
C20H24FN3O2S
Mol. Weight :
389.49
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Ibiglustat functions as a potent, orally active, and CNS‑penetrant inhibitor of glucosylceramide synthase. Its pharmacological profile supports its use in diverse glycosphingolipid‑related disorders, including Gaucher disease type 3, Parkinson’s disease linked to GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.

References : Viel C. et al.: Sci. Rep., 11(1), 20945, 2021; Peterschmitt M. J. et al.: Clin. Pharmacol. Drug Dev., 10(1), 86-98, 2021; Stojkovska I. et al.: Cell Tissue Res., 373(1), 51-60, 2018; Itier J. M. et al.: J. Inherit. Metab. Dis., 37(6), 1013-22, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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