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Icomidocholic acid

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SI-6105

Icomidocholic acid, >98% (HPLC)

CAS No. : [246529-22-6]

Synonyms : Aramchol; C20-FABAC

IUPAC Name : (4R)-4-((3S,5S,7R,9S,10S,12S,13R,14S,17R)-7,12-Dihydroxy-3-icosanamido-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

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Chemical Properites
Mol. Formula :
C44H79NO5
Mol. Weight :
702.12
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Icomidocholic acid formed from cholic acid and arachidic acid, functions as an orally active SCD1 inhibitor with cholesterol‑solubilizing and antifibrotic effects. It lowers liver fat content, disrupts cholesterol‑crystal formation, and protects against gallstone development, making it a valuable tool for NAFLD and NASH research.

References : Bhattacharya D. et al.: JHEP Rep., 3(3), 100237, 2021; Iruarrizaga-Lejarreta M. et al.: Hepatol. Commun., 1(9), 911-927, 2017; Gilat T. et al.: Lipids, 36(10), 1135-40, 2001.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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